diff --git a/image_analysis/IndexAndRefine.cpp b/image_analysis/IndexAndRefine.cpp
index f3423b0b..7c8a9c12 100644
--- a/image_analysis/IndexAndRefine.cpp
+++ b/image_analysis/IndexAndRefine.cpp
@@ -70,6 +70,9 @@ IndexAndRefine::IndexingOutcome IndexAndRefine::DetermineLatticeAndSymmetry(Data
         return outcome;
 
     auto latt = indexer_result.lattice[0];
+    if (latt.CalcVolume() < 1.0)
+        return outcome;
+
     auto sg = experiment.GetGemmiSpaceGroup();
 
     // If space group and cell provided => always enforce symmetry in refinement