diff --git a/configure/os/CONFIG.Common.RHEL10-x86_64 b/configure/os/CONFIG.Common.RHEL10-x86_64
new file mode 100644
index 000000000..49b19c524
--- /dev/null
+++ b/configure/os/CONFIG.Common.RHEL10-x86_64
@@ -0,0 +1,15 @@
+# Include definitions common to linux pentium targets
+include $(CONFIG)/os/CONFIG.Common.linux-x86_64
+
+BUILD_CLASS = HOST
+
+TOOLSET_LOCATION = /opt/rh
+TOOLSET = gcc-toolset-15
+STD_CXXFLAGS = -std=c++20
+STD_CFLAGS = -std=c17
+
+ifneq (($(TOOLSET)),)
+# Perl requests (native) annobin incompatible with the annobin from any TOOLSET
+# Disable Perl specific CFLAGS
+override Cap5_CFLAGS=
+endif
diff --git a/configure/os/CONFIG.Common.RHEL10-x86_64-clang b/configure/os/CONFIG.Common.RHEL10-x86_64-clang
new file mode 100644
index 000000000..b07b8b65e
--- /dev/null
+++ b/configure/os/CONFIG.Common.RHEL10-x86_64-clang
@@ -0,0 +1,5 @@
+include $(CONFIG)/os/CONFIG.Common.linux-clang
+
+BUILD_CLASS = HOST
+
+STD_CXXFLAGS = -std=c++2a
diff --git a/configure/os/CONFIG.RHEL10-x86_64.Common b/configure/os/CONFIG.RHEL10-x86_64.Common
new file mode 100644
index 000000000..26c65b727
--- /dev/null
+++ b/configure/os/CONFIG.RHEL10-x86_64.Common
@@ -0,0 +1,3 @@
+#CONFIG.$(EPICS_HOST_ARCH).Common is required by build system
+#Include definitions common to linux hosts
+include $(CONFIG)/os/CONFIG.linux-x86_64.Common
diff --git a/configure/os/CONFIG.RHEL10-x86_64.RHEL10-x86_64 b/configure/os/CONFIG.RHEL10-x86_64.RHEL10-x86_64
new file mode 100644
index 000000000..2bf7aace1
--- /dev/null
+++ b/configure/os/CONFIG.RHEL10-x86_64.RHEL10-x86_64
@@ -0,0 +1,2 @@
+# Include common linux definitions
+include $(CONFIG)/os/CONFIG.linux-x86.linux-x86
diff --git a/configure/os/CONFIG.RHEL10-x86_64.RHEL8-x86_64 b/configure/os/CONFIG.RHEL10-x86_64.RHEL8-x86_64
new file mode 100644
index 000000000..1ddec0cdd
--- /dev/null
+++ b/configure/os/CONFIG.RHEL10-x86_64.RHEL8-x86_64
@@ -0,0 +1,25 @@
+# Include common linux definitions
+include $(CONFIG)/os/CONFIG.linux-x86.linux-x86
+
+# "Cross compile" for RHEL8-x86_64
+# Expects RHEL8 RPMs gcc-toolset-12-gcc-c++ and readline-devel
+# to be installed in $(SYSROOT)
+# These can be installed on RHEL8 with:
+#    yum install --installroot=$(SYSROOT) <packages>
+# (Assuming $(SYSROOT) is on a shared network volume.)
+
+SYSROOT = /opt/RHEL8
+
+# "Cross" TOOLSET progs need to find their libraries.
+# But linker gets confused with LD_LIBRARY_PATH.
+# Thus only wrap the compiler.
+WRAPPER = -wrapper env,LD_LIBRARY_PATH=$(TOOLSET_DIR:%=$(SYSROOT)%/usr/lib64:)/usr/lib64:$(SYSROOT)/usr/lib64
+CPPFLAGS += $(WRAPPER)
+
+# These programs as cross tools would also need LD_LIBRARY_PATH.
+# But but our host versions work just fine.
+AR = ar -rc
+RANLIB = ranlib
+
+# Allow to run cross-tests which expect different lib versions
+export LD_PRELOAD=$(SYSROOT)/lib64/libreadline.so
diff --git a/configure/os/CONFIG.RHEL10-x86_64.RHEL9-x86_64 b/configure/os/CONFIG.RHEL10-x86_64.RHEL9-x86_64
new file mode 100644
index 000000000..a31d786d4
--- /dev/null
+++ b/configure/os/CONFIG.RHEL10-x86_64.RHEL9-x86_64
@@ -0,0 +1,25 @@
+# Include common linux definitions
+include $(CONFIG)/os/CONFIG.linux-x86.linux-x86
+
+# "Cross compile" for RHEL9-x86_64
+# Expects RHEL9 RPMs gcc-toolset-15-gcc-c++ and readline-devel
+# to be installed in $(SYSROOT)
+# These can be installed on RHEL9 with:
+#    yum install --installroot=$(SYSROOT) <packages>
+# (Assuming $(SYSROOT) is on a shared network volume.)
+
+SYSROOT = /opt/RHEL9
+
+# "Cross" TOOLSET progs need to find their libraries.
+# But linker gets confused with LD_LIBRARY_PATH.
+# Thus only wrap the compiler.
+WRAPPER = -wrapper env,LD_LIBRARY_PATH=$(TOOLSET_DIR:%=$(SYSROOT)%/usr/lib64:)/usr/lib64:$(SYSROOT)/usr/lib64
+CPPFLAGS += $(WRAPPER)
+
+# These programs as cross tools would also need LD_LIBRARY_PATH.
+# But but our host versions work just fine.
+AR = ar -rc
+RANLIB = ranlib
+
+# Allow to run cross-tests which expect different lib versions
+export LD_PRELOAD=$(SYSROOT)/lib64/libreadline.so
diff --git a/configure/os/CONFIG.RHEL10-x86_64.windows-x64 b/configure/os/CONFIG.RHEL10-x86_64.windows-x64
new file mode 100644
index 000000000..f79e7a452
--- /dev/null
+++ b/configure/os/CONFIG.RHEL10-x86_64.windows-x64
@@ -0,0 +1 @@
+include $(CONFIG)/os/CONFIG.Linux.windows-x64
diff --git a/configure/os/CONFIG.RHEL10-x86_64.windows-x64-mingw b/configure/os/CONFIG.RHEL10-x86_64.windows-x64-mingw
new file mode 100644
index 000000000..58484c14e
--- /dev/null
+++ b/configure/os/CONFIG.RHEL10-x86_64.windows-x64-mingw
@@ -0,0 +1 @@
+include  $(CONFIG)/os/CONFIG.linux-x86_64.windows-x64-mingw
diff --git a/configure/os/CONFIG_SITE.RHEL10-x86_64.Common b/configure/os/CONFIG_SITE.RHEL10-x86_64.Common
new file mode 100644
index 000000000..e90a792ae
--- /dev/null
+++ b/configure/os/CONFIG_SITE.RHEL10-x86_64.Common
@@ -0,0 +1,13 @@
+include $(CONFIG)/os/CONFIG_SITE.linux-x86_64.Common
+
+# Improved error checking with clang
+CROSS_COMPILER_TARGET_ARCHS += RHEL10-x86_64-clang
+CROSS_COMPILER_RUNTEST_ARCHS += RHEL10-x86_64-clang
+
+# Build for old RHEL9 64 bit 
+CROSS_COMPILER_TARGET_ARCHS += RHEL9-x86_64
+CROSS_COMPILER_RUNTEST_ARCHS += RHEL9-x86_64
+
+# Build for old RHEL8 64 bit
+CROSS_COMPILER_TARGET_ARCHS += RHEL8-x86_64
+CROSS_COMPILER_RUNTEST_ARCHS += RHEL8-x86_64
diff --git a/configure/os/CONFIG_SITE.RHEL10-x86_64.windows-x64-mingw b/configure/os/CONFIG_SITE.RHEL10-x86_64.windows-x64-mingw
new file mode 100644
index 000000000..06511db26
--- /dev/null
+++ b/configure/os/CONFIG_SITE.RHEL10-x86_64.windows-x64-mingw
@@ -0,0 +1 @@
+include  $(CONFIG)/os/CONFIG_SITE.linux-x86_64.windows-x64-mingw