diff --git a/bec_widgets/utils/bec_signal_proxy.py b/bec_widgets/utils/bec_signal_proxy.py
index 8c648769..aff6cb17 100644
--- a/bec_widgets/utils/bec_signal_proxy.py
+++ b/bec_widgets/utils/bec_signal_proxy.py
@@ -22,11 +22,15 @@ def cleanup_signal_proxy(proxy: SignalProxy) -> None:
     Args:
         proxy(SignalProxy): The proxy to stop.
     """
+    # A repeated SignalProxy.disconnect makes PySide6 warn "Failed to disconnect".
+    if getattr(proxy, "_bec_cleaned_up", False):
+        return
     # Called explicitly: on subclasses of SignalProxy, PySide6 resolves proxy.disconnect
     # to the built-in QObject.disconnect instead of SignalProxy.disconnect.
     SignalProxy.disconnect(proxy)
     proxy.timer.stop()
     proxy.args = None
+    proxy._bec_cleaned_up = True
 
 
 class BECSignalProxy(SignalProxy):
diff --git a/tests/unit_tests/test_utils_bec_signal_proxy.py b/tests/unit_tests/test_utils_bec_signal_proxy.py
index b093c56e..61f0cc77 100644
--- a/tests/unit_tests/test_utils_bec_signal_proxy.py
+++ b/tests/unit_tests/test_utils_bec_signal_proxy.py
@@ -1,3 +1,4 @@
+import warnings
 from unittest import mock
 
 import pyqtgraph as pg
@@ -256,4 +257,7 @@ def test_cleanup_signal_proxy_stops_queued_delivery(qtbot):
     assert calls == []
     assert ticks == []
     assert not proxy.timer.timer.isActive()
-    cleanup_signal_proxy(proxy)  # a second call is a no-op
+    with warnings.catch_warnings(record=True) as caught:
+        warnings.simplefilter("always")
+        cleanup_signal_proxy(proxy)  # a second call is a no-op, without PySide warnings
+    assert [str(w.message) for w in caught] == []