diff --git a/bec_widgets/applications/views/developer_view/developer_widget.py b/bec_widgets/applications/views/developer_view/developer_widget.py
index ce7030c3..acb56d22 100644
--- a/bec_widgets/applications/views/developer_view/developer_widget.py
+++ b/bec_widgets/applications/views/developer_view/developer_widget.py
@@ -124,6 +124,7 @@ class DeveloperWidget(DockAreaWidget):
         # Connect editor signals
         self.explorer.file_open_requested.connect(self._open_new_file)
         self.monaco.macro_file_updated.connect(self.explorer.refresh_macro_file)
+        self.monaco.focused_editor.connect(self._on_focused_editor_changed)
 
         self.toolbar.show_bundles(["save", "execution", "settings"])
 
@@ -336,6 +337,28 @@ class DeveloperWidget(DockAreaWidget):
                 self.on_script_execution_info, MessageEndpoints.script_execution_info(new_script_id)
             )
 
+    @SafeSlot(CDockWidget)
+    def _on_focused_editor_changed(self, tab_widget: CDockWidget):
+        """
+        Disable the run / stop buttons if the focused editor is a macro file.
+        Args:
+            tab_widget: The currently focused tab widget in the Monaco editor.
+        """
+        if not isinstance(tab_widget, CDockWidget):
+            return
+        widget = tab_widget.widget()
+        if not isinstance(widget, MonacoWidget):
+            return
+        file_scope = widget.metadata.get("scope", "")
+        run_action = self.toolbar.components.get_action("run")
+        stop_action = self.toolbar.components.get_action("stop")
+        if "macro" in file_scope:
+            run_action.action.setEnabled(False)
+            stop_action.action.setEnabled(False)
+        else:
+            run_action.action.setEnabled(True)
+            stop_action.action.setEnabled(True)
+
     @SafeSlot(dict, dict)
     def on_script_execution_info(self, content: dict, metadata: dict):
         """
diff --git a/tests/unit_tests/test_developer_view.py b/tests/unit_tests/test_developer_view.py
index 56971d3b..f4b756fc 100644
--- a/tests/unit_tests/test_developer_view.py
+++ b/tests/unit_tests/test_developer_view.py
@@ -322,6 +322,52 @@ class TestToolbarIntegration:
             # Check that state changed
             assert vim_action.action.isChecked() != initial_state
 
+    def test_run_stop_buttons_disabled_for_macros(self, developer_view, temp_python_file, qtbot):
+        """Test that run and stop buttons are disabled when a macro file is focused."""
+        # Open a file with macro scope
+        developer_view._open_new_file(temp_python_file, "macros/local")
+
+        qtbot.waitUntil(
+            lambda: temp_python_file in developer_view.monaco._get_open_files(), timeout=2000
+        )
+
+        # Get the editor dock for the macro file
+        dock = developer_view.monaco._get_editor_dock(temp_python_file)
+        assert dock is not None
+
+        # Simulate focusing on the macro file
+        developer_view._on_focused_editor_changed(dock)
+
+        # Check that run and stop buttons are disabled
+        run_action = developer_view.toolbar.components.get_action("run")
+        stop_action = developer_view.toolbar.components.get_action("stop")
+
+        assert not run_action.action.isEnabled()
+        assert not stop_action.action.isEnabled()
+
+    def test_run_stop_buttons_enabled_for_scripts(self, developer_view, temp_python_file, qtbot):
+        """Test that run and stop buttons are enabled when a script file is focused."""
+        # Open a file with script scope
+        developer_view._open_new_file(temp_python_file, "scripts/local")
+
+        qtbot.waitUntil(
+            lambda: temp_python_file in developer_view.monaco._get_open_files(), timeout=2000
+        )
+
+        # Get the editor dock for the script file
+        dock = developer_view.monaco._get_editor_dock(temp_python_file)
+        assert dock is not None
+
+        # Simulate focusing on the script file
+        developer_view._on_focused_editor_changed(dock)
+
+        # Check that run and stop buttons are enabled
+        run_action = developer_view.toolbar.components.get_action("run")
+        stop_action = developer_view.toolbar.components.get_action("stop")
+
+        assert run_action.action.isEnabled()
+        assert stop_action.action.isEnabled()
+
 
 class TestErrorHandling:
     """Test error handling in various scenarios."""